. this sort of experiments are identified as mutation accumulation (MA) experiments (Elena and Lenski 2003; Lind and Andersson 2008; Brockhurst et al. 2010). it's now attainable to stick to up MA experiments with full-genome sequencing with the ancestor strain and its ensuing progeny, Consequently permitting for that genome-extensive identification

for this reason, the digestion of exactly the same DNA sample with HspI and MspI, and electrophoretic analysis of the size in the digestion items, can reveal the location in the web sites of DNA methylation. This approach has also been adapted to a way for whole genome scanning [86]. The earliest and probably most recognizable of the epigenetic ma